1-对氯苄基-2-(1-吡咯烷基)甲基苯并咪唑盐酸盐

产品名称：

1163-36-6
Clemizole Hydrochloride
1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride
1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride
1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole hydrochloride
CID 2782 hydrochloride
NSC 46261 hydrochloride
克立咪唑盐酸盐
1-对氯苄基-2-(1-吡咯烷基)甲基苯并咪唑盐酸盐

产品介绍：

产品说明

一般描述

Clemizole is a potent anti-allergic drug.

包装

5, 25 mg in glass bottle

生化/生理作用

Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1α (sodium channel, voltage-gated, type I, α) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment.
Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1:TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture.

基本信息

经验(实验)分子式	C₁₉H₂₀ClN₃ · HCl
分子量	362.30
EC 号	214-605-4
MDL编号	MFCD00051435
PubChem化学物质编号	329825887

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	H₂O: 2 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	ClC(C=C1)=CC=C1CN2C(CN3CCCC3)=NC4=CC=CC=C42.[H]Cl
InChI	1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
InChI key	DNFMJYXRIMLMBZ-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Clemizole Hydrochloride

克立咪唑 盐酸盐

克立咪唑盐酸盐