产品说明
生化/生理作用
Compound 8918 is an orally active, non-cytotoxic, phosphopantethein (Ppt)-binding pocket-targeting, non-competitive M. tuberculosis (Mtb) Ppt transferase (PptT) inhibitor (IC50 = 2.5 μM, Emax 80-90%) that exhibits mycobactericidal activity (MIC90 = 0.56-3 μM/29 clinical Mtb isolates; MBC99 = 6.25 μM/Mtb, 3.13 μM/M. smegmatis) with no bactericidal potency against S. aureus, E. coli, P. aeruginosa, Streptomyces or C. albicans. Oral administration is efficacious against H37Rv replication in mouse lung in vivo (by 100%; 100 mg/kg/d, 4 d/wk for 2 wks). Mutations in MtbH37Rv rv2794c (PptT) or rv279c (Ppt hydrolase, PptH) gene confers 8918 resistance.
基本信息
| 经验(实验)分子式 | C14H22N4O |
| 分子量 | 262.35 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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