DJ-V-159

产品名称：

2253744-53-3
DJ-V-159
N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-1,3-Benzenedicarboxamide
N1,N3-Bis(4-cyano-3-(trifluoromethyl)phenyl)isophthalamide

产品介绍：

产品说明

生化/生理作用

DJ-V-159 is an agonist of GPRC6A, a family C G protein coupled receptor proposed to be master regulator of energy metabolism. GPRC6A is the receptor for osteocalcin, basic amino acids (e.g., L-Arginine), cations (e.g., calcium), and is a membrane receptor for testosterone. DJ-V-159 activated GPRC6A at 0.2 nM concentrations and stimulated GPRC6A-mediated ERK phosphorylation and cAMP accumulation in GPRC6A expressing HEK-293 cells. DJ-V-159 was found to stimulate insulin secretion from mouse β-cells and and lower serum glucose in wild-type mice.

基本信息

经验(实验)分子式	C₂₄H₁₂F₆N₄O₂
分子量	502.37
MDL编号	MFCD31807620

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(C1=CC(C(NC2=CC=C(C#N)C(C(F)(F)F)=C2)=O)=CC=C1)NC3=CC(C(F)(F)F)=C(C#N)C=C3

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable