CP-31398 二盐酸盐水合物

产品名称：

CP-31398 dihydrochloride hydrate
N′-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride hydrate
CP-31398 二盐酸盐水合物

产品介绍：

产品说明

应用

CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:

to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
to study its effects on regulation of miR-34 in PC12 cells

包装

5, 25 mg in glass bottle

生化/生理作用

CP-31398 is a styryl quinazoline that functions in preserving the activity of p53 as a tumor suppressor and transcription factor. The DNA-binding activity and apoptosis functionality of the p53 are restored by CP-31398. CP-31398 exhibits therapeutic effects against liver, skin, pancreatic, and colon cancers.
CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

特点和优势

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

其他说明

This compound was developed by Pfizer for Apoptosis & Cell Cycle research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₂₂H₂₆N₄O·2HCl · xH₂O
分子量	435.39 (anhydrous basis)
MDL编号	MFCD17215956
PubChem化学物质编号	329823707
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
manufacturer/tradename	Pfizer^®
储存条件	desiccated
颜色	yellow
溶解性	H₂O: ≥20 mg/mL
创始人	Pfizer
储存温度	2-8℃
SMILES string	O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2
InChI	1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;
InChI key	JXIVIAMOMIONKY-UWCBQFGESA-N
Gene Information	human ... TP53(7157) mouse ... TP53(22059) rat ... TP53(24842)

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H413
预防措施声明	P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

CP-31398 dihydrochloride hydrate

CP-31398 二盐酸盐 水合物

CP-31398 二盐酸盐水合物