DIM-C-pPhCO2Me

产品名称：

151358-48-4
DIM-C-pPhCO2Me
Benzoic acid, 4-(di-1H-indol-3-ylmethyl)-, methyl ester
4-(di-1H-Indol-3-ylmethyl)-benzoic acid methyl ester

产品介绍：

产品说明

生化/生理作用

DIM-C-pPhCO2Me is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhCO2Me decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231 breast cancer cells. DIM-C-pPhCO2Me inhibits migration of Rh30 and MDA-MB-231 cancer cells.
DIM-C-pPhCO₂Me is also known as 1,1-bis(3′-indolyl)-1-(p-carboxymethylphenyl)methane. In pancreatic and colon cancer cells, DIM-C-pPhCO₂Me plays an inhibitory role on cell migration. DIM-C-pPhCO₂Me prevents the action of mechanistic target of rapamycin (mTOR) and reduces the multiplication and survival of cancer cells. It stimulates reactive oxygen species (ROS) in various cancer cell lines.

基本信息

经验(实验)分子式	C₂₅H₂₀N₂O₂
分子量	380.44
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	pink to light red
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(OC)C1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=CC=CC=C54)C=C1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable