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GeA-69

品牌
Sigma-Aldrich
CAS
2143475-98-1
货号
SML2267
规格纯度
≥98% (HPLC)
参考价格
798.09 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
2143475-98-1
GeA-69
N-[2-(9H-Carbazol-1-yl)phenyl]-acetamide
产品介绍:

产品说明

生化/生理作用

GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites.

基本信息

经验(实验)分子式C20H16N2O
分子量300.35
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 off-white to brown
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringCC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43)=O

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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