GeA-69

产品名称：

2143475-98-1
GeA-69
N-[2-(9H-Carbazol-1-yl)phenyl]-acetamide

产品介绍：

产品说明

生化/生理作用

GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites.

基本信息

经验(实验)分子式	C₂₀H₁₆N₂O
分子量	300.35
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	off-white to brown
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	CC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable