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位置:首页 > 品牌 > Sigma-Aldrich > 3β-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene

Galeterone

品牌
Sigma-Aldrich
CAS
851983-85-2
货号
SML1375
规格纯度
≥98% (HPLC)
参考价格
1117.23 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
851983-85-2
Galeterone
VN/124-1
VN-124-1
TOK-001
3β-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Galeterone is an inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17-α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Galeterone, moreover, is a potent blocker of the androgen receptor and causes down-regulation of androgen receptor (AR) protein expression in vitro and in vivo.

基本信息

经验(实验)分子式C26H32N2O
分子量388.55
MDL编号MFCD16660907
PubChem化学物质编号329825826
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 20 mg/mL, clear
储存温度−20℃
SMILES stringC[C@]12C(C[C@@H](O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4N5C=NC6=C5C=CC=C6
InChI1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1
InChI keyPAFKTGFSEFKSQG-PAASFTFBSA-N
Gene Informationhuman ... AR(367), CYP17A1(1586)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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