3β-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene

产品名称：

851983-85-2
Galeterone
VN/124-1
VN-124-1
TOK-001
3β-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Galeterone is an inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17-α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Galeterone, moreover, is a potent blocker of the androgen receptor and causes down-regulation of androgen receptor (AR) protein expression in vitro and in vivo.

基本信息

经验(实验)分子式	C₂₆H₃₂N₂O
分子量	388.55
MDL编号	MFCD16660907
PubChem化学物质编号	329825826
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	−20℃
SMILES string	C[C@]12C(C[C@@H](O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4N5C=NC6=C5C=CC=C6
InChI	1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1
InChI key	PAFKTGFSEFKSQG-PAASFTFBSA-N
Gene Information	human ... AR(367), CYP17A1(1586)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable