GSK4112

产品名称：

GSK4112
1,1-Dimethylethyl N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
SR6452

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

GSK4112 is a rev-erbα, (orphan nuclear receptor NR1D1) agonist, the first agent able to reset the circadian clock in a phase-dependent manner. Rev-erbα impacts the precision of the circadian clock by repressing target gene activities with the help of a nuclear receptor co-repressor complex (NCoR) and HDAC3. GSK4112 competes with heme (rev-erb′s natural ligand) and enhances co-repressor complex recruitment and thus, repression of transcription. suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases, especially disorders of adipogenesis regulated by rev-erba.

特点和优势

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₁₈H₂₁ClN₂O₄S
分子量	396.89
MDL编号	MFCD12912412
PubChem化学物质编号	329799818
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	off-white to tan
溶解性	DMSO: >20 mg/mL
创始人	GlaxoSmithKline
储存温度	2-8℃
SMILES string	CC(C)(C)OC(=O)CN(Cc1ccc(Cl)cc1)Cc2ccc(s2)[N+]([O-])=O
InChI	1S/C18H21ClN2O4S/c1-18(2,3)25-17(22)12-20(10-13-4-6-14(19)7-5-13)11-15-8-9-16(26-15)21(23)24/h4-9H,10-12H2,1-3H3
InChI key	WYSLOKHVFKLWOU-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H318 - H334
预防措施声明	P261 - P280 - P305 + P351 + P338 - P342 + P311
危险分类	Eye Dam. 1 - Resp. Sens. 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable