IMS2186

产品名称：

1031206-36-6
IMS2186
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC₅₀= 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.

基本信息

经验(实验)分子式	C₁₈H₁₆O₄
分子量	296.32
MDL编号	MFCD12912419
PubChem化学物质编号	329815315
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
储存条件	desiccated
颜色	white to off-white
溶解性	DMSO: >20 mg/mL
储存温度	room temp
SMILES string	COc1ccc(cc1O)\C=C2/COc3ccc(C)cc3C2=O
InChI	1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+
InChI key	BZCADTHMZLYKAR-MDWZMJQESA-N

安全信息

象形图
警示用语：	Warning
危险声明	H400
预防措施声明	P273
危险分类	Aquatic Acute 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves