KRN2

产品名称：

248260-75-5
KRN2
13-[(2-Fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride

产品介绍：

产品说明

生化/生理作用

KRN2 is a specific and potent inhibitor of nuclear factor of activated T cells 5 (NFAT5) that inhibits formation of NF-κB p65-DNA complexes. KRN2 suppresses migration of Fibroblast-like synoviocytes stimulated with TGF-β. KRN2 ameliorates experimental arthritis in mice.
KRN2 or 13-(2-fluorobenzyl)-berberine is a berberine derivative that effectively blocks the invasiveness of fibroblast-like synoviocytes (FLS). It is stable and orally bioavailable. It suppresses the production of proinflammatory cytokines to ameliorate arthritis severity.

基本信息

经验(实验)分子式	C₂₇H₂₃FClNO₄
分子量	479.93
MDL编号	MFCD31728343

产品性质

测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	faint yellow to dark orange
溶解性	H₂O: 2 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	FC(C=CC=C1)=C1CC2=C([N+](CC3)=CC4=C2C=CC(OC)=C4OC)C5=C3C=C(OCO6)C6=C5.[Cl-]

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable