6β-乙酰氧基-1α,7β,9α-三羟基-8,13-环氧-异佛司可林-14-烯-11-酮

产品名称：

64657-21-2
Isoforskolin
(3R,6S,6aS)-6-(acetyloxy)-3-ethenyldodecahydro-5S,10S,10bS-trihydroxy-3,4aR,7,7,10aR-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
6-Acetyl-7-deacetylforskolin
6β-Acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one
Coleonol B
6-乙酰-7-脱乙酰福斯考灵
6β-乙酰氧基-1α,7β,9α-三羟基-8,13-环氧-异佛司可林-14-烯-11-酮
异佛司可林

产品介绍：

产品说明

生化/生理作用

Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.

基本信息

经验(实验)分子式	C₂₂H₃₄O₇
分子量	410.50
MDL编号	MFCD00078929

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
旋光性	[α]/D -8 to -5°, c = 0.5 in chloroform-d
颜色	white to beige
溶解性	DMF:H₂O (9:1): 2 mg/mL, clear
储存温度	−20℃
SMILES string	CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C
InChI	1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1
InChI key	CLOQVZCSBYBUPB-VDCUXWMXSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H312
预防措施声明	P280 - P302 + P352 + P312 - P362 + P364 - P501
危险分类	Acute Tox. 4 Dermal
储存分类代码	11 - Combustible Solids
WGK	WGK 3