2-(1′H-Indole-3′-carbonyl)thiazole-4-carboxylic acid methyl ester

产品名称：

448906-42-1
ITE
2-(1H-Indole-3-carbonyl)thiazole--4--carboxylic acid methyl ester
Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate
2-(1′H-Indole-3′-carbonyl)thiazole-4-carboxylic acid methyl ester
2-(1’H-Indole-3′-carbonyl)-thiazole-4-carboxylic acid

产品介绍：

产品说明

生化/生理作用

ITE is an endogenous aryl hydrocarbon (Ah) receptor (AhR) agonist with broad-spectrum species reactivity and 5-fold higher potency than beta-naphthoflavone (by cell-based reporter assay). ITE upregulates CYP1A1/downregulates AhR in Hepa cells (0.1-5 μM), and induces fetus AhR activation in pregnant mice in vivo (1.4mg ITE/mL DMSO/kg bw i.v. on gestation day/GD 14, fetal AhR activation assessed on GD15).
Endogenous ligand identified for aryl hydrocarbon receptor (AHR); ligand inducible transcription factor.

基本信息

经验(实验)分子式	C₁₄H₁₀N₂O₃S
分子量	286.31
MDL编号	MFCD06411597

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	COC(=O)c1csc(n1)C(=O)c2c[nH]c3ccccc23

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable