7-Chloro-5-(2′-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one

产品名称：

1802013-08-6
ITH12575
4,1-Benzothiazepin-2(3H)-one, 7-chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-
7-Chloro-5-(2′-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one

产品介绍：

产品说明

生化/生理作用

ITH12575 is apotent and selective inhibitor of mitochondrial Na+/Ca2+ exchanger mNCX with neuroprotective activity. It was shown to reduce Ca2+ efflux from the mitochondria to the cytosol with an EC50 value of 690 nM and was shown to protect against Ca2+ overload and mitigated the neuronal damage in a model of oxidative stress. At higher concentrations ITH12575 also reduced Ca2+ influx through CALHM1, a Ca2+ channel that plays a key role in the neuronal electrical activity.

基本信息

经验(实验)分子式	C₁₈H₁₈ClNOS
分子量	331.86
MDL编号	MFCD30720887
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	CC(C)C1=C(C2C(C=C(Cl)C=C3)=C3NC(CS2)=O)C=CC=C1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable