(S)-2-((4′-(Trifluoromethyl)biphenyl-4-yl)methylamino)propanamide methanesulfonate

产品名称：

1894207-45-4
KDS2010
(S)-2-((4′-(Trifluoromethyl)biphenyl-4-yl)methylamino)propanamide methanesulfonate
(S)-2-(((4′-Trifluoromethylbiphenyl-4-yl)methyl)amino)propanamide methanesulfonate

产品介绍：

产品说明

生化/生理作用

KDS2010 is a highly selective, substrate-competitive, potent and reversible monoamine oxidase MAO-B inhibitor (IC50 = 7.6 nM/MAO-B vs >100 μM/MAO-A; little affinity toward 99 kinases and 84 non-kinase targets) with excellent ADME/Tox profiles (IC50 >10 μM/P450, >50 μM/hERG), brain permeability and oral availability ([rat F = 123.5%; 10 mg/kg p.o.). KDS2010 restores memory impairments in APP/PS1 mice following either short- or long-term treatment (3-d or 4-wk 10 mg/kg/day p.o.) without aberrant GABA levels observed with prolonged irreversible inhibition by selegiline (MAO-B/MAO-A IC50 = 10 nM/1.5 μM) due to compensatory diamine oxidase (DAO) induction.

基本信息

经验(实验)分子式	C₁₇H₁₇F₃N₂O · CH₃SO₃H
分子量	418.43

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	H₂O: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable