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Nifetepimine

品牌
Sigma-Aldrich
CAS
110448-29-8
货号
SML1372
包装型号
规格纯度
≥95% (HPLC)
参考价格
4498.97 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
110448-29-8
Nifetepimine
1,2,3,4-Tetrahydro-6-methyl-4-(3-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid ethyl ester
5-Ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one
6-Methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester
Ethyl-4-(3-nitrophenyl)-6-methyl-2-oxo-1,2,3,4 tetrahydropyrimidine-5 carboxylate
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Nifetepimine is a dihydropyrimidone calcium channel blocker that down-modulates SERCA3 (sarco/endoplasmic reticulum Ca2+ -ATPase 3) pump, and protects of the CD4+ T cells from tumor-induced apoptosis. Nifetepimine induces apoptotic cell death in triple negative breast cancer (TNBC) cells by stimulation of cross-talk between ER stress and the MEK/ERK pathway.

基本信息

经验(实验)分子式C14H15N3O5
分子量305.29
MDL编号MFCD00128568
PubChem化学物质编号329825824
NACRESNA.77

产品性质

质量水平100
测定≥95% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 10 mg/mL, clear
储存温度2-8℃
SMILES stringO=C(OCC)C1=C(C)NC(NC1C2=CC([N+]([O-])=O)=CC=C2)=O
InChI1S/C14H15N3O5/c1-3-22-13(18)11-8(2)15-14(19)16-12(11)9-5-4-6-10(7-9)17(20)21/h4-7,12H,3H2,1-2H3,(H2,15,16,19)
InChI keyPPBNQKLDXXHPMH-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H319
预防措施声明P280 - P301 + P312 + P330 - P305 + P351 + P338 - P337 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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