Oxidized Nifedipine

产品名称：

67035-22-7
Oxidized Nifedipine
2,6-Dimethyl-4-(2'-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester

产品介绍：

产品说明

应用

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.
Oxidized Nifedipine may be used:

to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes
in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)

包装

5, 10 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

生化/生理作用

Nifedipine is a dihydropyridine derivative and a calcium channel blocker. It is used in treating hypertension and angina pectoris. Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light. The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.
CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. UC167.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

基本信息

经验(实验)分子式	C₁₇H₁₆N₂O₆
分子量	344.32
MDL编号	MFCD00153847
PubChem化学物质编号	329827652
NACRES	NA.77

产品性质

测定	~95% (HPLC)
形式	powder
颜色	yellow
mp	100-105 ℃
储存温度	2-8℃
SMILES string	COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O
InChI	1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3
InChI key	UMQHJQGNGLQJPF-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H318
预防措施声明	P280 - P305 + P351 + P338
危险分类	Eye Dam. 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves