RN-9893

产品名称：

1803003-68-0
RN-9893
N-(4-(4-Isopropylpiperazin-1-ylsulfonyl)phenyl)-2-nitro-4-(trifluoromethyl)benzamide

产品介绍：

产品说明

一般描述

RN-9893 is a small, orally bioavailable antagonist of TRPV4 (transient receptor potential subfamily V4. It is a tri-substituted benzamide compound.

包装

5, 25 mg in glass bottle

生化/生理作用

RN-9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4. RN-9893 has IC₅₀ values of 420 nM, 660 nM, and 320 nM for human, rat and mouse TRPV4 receptors, respectively. RN-9893 shows excellent selectivity over related TRP receptors with no inhibition of TRPV1 at a concentration of 10 μM, an IC₅₀ >30 μM against TRPV3, an IC₅₀ of approximately 30 μM against TRPM8, and also good selectivity using 54 binding assays against common biological targets.

基本信息

经验(实验)分子式	C₂₁H₂₃F₃N₄O₅S
分子量	500.49
PubChem化学物质编号	329825956

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 25 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(NC1=CC=C(S(=O)(N2CCN(C(C)C)CC2)=O)C=C1)C3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O
InChI	1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
InChI key	KORKKQLDGMHNKO-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable