SID 3712249

产品名称：

522606-67-3
SID 3712249
1,8-Diamino-3,6-di-1-pyrrolidinyl-2,7-naphthyridine-4-carbonitrile
MiR-544 Inhibitor 1
MLS000054131

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.

其他说明

light sensitive

基本信息

经验(实验)分子式	C₁₇H₂₁N₇
分子量	323.40
MDL编号	MFCD03483890
PubChem化学物质编号	329825935
NACRES	NA.77

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
储存条件	protect from light
颜色	white to brown
溶解性	DMSO: 15 mg/mL, clear
储存温度	room temp
SMILES string	NC1=C2C(C=C(N3CCCC3)N=C2N)=C(C#N)C(N4CCCC4)=N1
InChI	1S/C17H21N7/c18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22)
InChI key	SSWVPYMSHHEYAB-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable