Santacruzamate A

产品名称：

1477949-42-0
Santacruzamate A
CAY 10683
CAY-10683
N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]carbamic acid ethyl ester
CAY10683

产品介绍：

产品说明

生化/生理作用

Santacruzamate A (CAY10683) is a cell-permeable and bioavailable carbamate compound that potently inhibits HDAC2 (IC50 = 119 nM) selectively over HDAC4 and HDAC6 (IC50 = > 1 μM and 433.5 nM, respectively). CAY10683 readily enhances cellular acetylated HDAC2 levels upon LPS-stimulation and only modestly inhibits HuT-78 cutaneous T-cell lymphoma and HCT-116 colon carcinoma cells growth (GI50 = 1.4 and 29.4 uM, respectively). It alleviates acute liver failure (ALF) in rats (i.p.) and rescues cognitive deficits in APPswe/PS1dE9 mice (p.o.).

基本信息

经验(实验)分子式	C₁₅H₂₂N₂O₃
分子量	278.35
MDL编号	MFCD28348356

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C1

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable