Tazarotenic acid

产品名称：

118292-41-4
Tazarotenic acid
AGN 190299
6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid
AGN-190299
6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinic acid
Tazarotene acid

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Tazarotene is transformed to tazarotenic acid with the help of esterases. Tazarotenic acid regulates the pathogenic aspects of psoriasis through normalizing abnormal keratinocyte differentiation. It possesses strong anti-hyperproliferative effects in skin and reduces inflammation.
Tazarotenic acid, an active metabolite of tazarotene, is a potent and selective agonist of the retinoid receptor (RAR) that binds to RARα, RARβ, and RARγ. Tazarotenic acid relatively selective activates RARβ and RARγ. Tazarotenic acid is a first xenobiotic substrate of human retinoic acid hydroxylase CYP26A1 and CYP26B1.

基本信息

经验(实验)分子式	C₁₉H₁₇NO₂S
分子量	323.41
MDL编号	MFCD00872121
PubChem化学物质编号	329825505

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to light brown
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	CC1(C)CCSC2=C1C=C(C#CC3=CC=C(C(O)=O)C=N3)C=C2
InChI	1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22)
InChI key	IQIBKLWBVJPOQO-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable