SEW84

产品名称：

259089-67-3
SEW84
1-(4-Fluorophenyl)-1H-pyrrole-2-carboxylic acid 2-[thioxo[[3-(trifluoromethylphenyl]-amino]methyl]hydrazide

产品介绍：

产品说明

生化/生理作用

SEW84 is a potent and selective inhibitor of the Aha1-stimulated Hsp90 ATPase activity without inhibition of basal Hsp90 ATPase. It binds to the C-terminal domain of Aha1 and weakens the Hsp90-Aha1 interaction. SEW84 inhibits Aha1-dependent Hsp90 chaperoning activities including refolding of denatured firefly luciferase (in vitro) and in vivo transcriptional activity of the glucocorticoid receptor and AR androgen receptor in prostate cancer cell-based models. SEW84 preferentially clears Alzheimer disease related phosphorylated aggregation-prone Tau in primary rat cortical neurons.

基本信息

经验(实验)分子式	C₁₉H₁₄F₄N₄OS
分子量	422.40
MDL编号	MFCD01764773

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable