SHP1 Inhibitor, TPI-1

产品名称：

79756-69-7
SHP1 Inhibitor, TPI-1
2-(2,5-Dichlorophenyl)-2,5-cyclohexadiene-1,4-dione
TPI1
TPI-1
TPI 1
2-(2,5-Dichloro-phenyl)-[1,4]benzoquinone; 2-(2?,5?-Dichlorophenyl)-1,4-benzoquinone

产品介绍：

产品说明

生化/生理作用

TPI-1 is an orally bioavailable, noncytotoxic benzoquinone compound that acts as a potent irreversible inhibitor of SHP-1 (Src homology region 2 domain-containing phosphatase 1) catalytic domain (IC50 ~ 40 nM or 0.01 μg/ml) with selectivity over SHP-2 (IC50 ~ 0.1 μg/ml), MKP1 (IC50 > 1 μg/ml) and CD45. TPI-1 potently induces mouse and human primary IFN-g+ cells both in vitro and in vivo. Effectively inhibits B16 melanoma tumors in mice (1 or 3 mg/kg, s.c., daily) and prolong the survival. TPI-1 is shown to be 50-fold more effective than sodium stibogluconate in cell-based assays and may non-specifically react with cysteine residues.

基本信息

经验(实验)分子式	C₁₂H₆Cl₂O₂
分子量	253.08
MDL编号	MFCD00448731

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C1C=CC(C(C2=C(C=CC(Cl)=C2)Cl)=C1)=O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable