您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > TETi76 diethyl ester

TETi76 diethyl ester

品牌
Sigma-Aldrich
CAS
1451750-73-4
货号
SML3121
规格纯度
≥95% (GC)
参考价格
1222.97 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
1451750-73-4
TETi76 diethyl ester
AD145
Diethyl 2-hydroxy-4-methylenepentanedioate
TETi76 ester
2-Hydroxy-4-methylene-pentanedioic acid, 1,5-diethyl ester
产品介绍:

产品说明

生化/生理作用

TETi76 diethyl ester is a cell-permeant diester form of the α-KG-competitive and hightly selective TET1/2/3 dioxygenase inhibitor TETi76 acid (TET2 cat. domain Kd = 0.3 μM; no potency against 16 other αKG/Fe2+-dependent enzymes, including closely related RNA dioxygenase FTO). TETi76 ester downregulates cellular 5-hydroxymethylcytosine (5hmC) levels (IC50 = 20-37 μM; K562, MEG01, SIGM5, OCI-AML5, MOLM13), exerts preferential cytotoxicity in TET-deficient cultures (TET2/3-knockout K562 LD50 ~10 μM vs wt K562 LD50 ~40 μM) and significantly reduces TET2-deficient SIGM5 tumor burden in mice in vivo (50 mg/kg p.o.).

基本信息

经验(实验)分子式C10H16O5
分子量216.23

产品性质

质量水平100
测定≥95% (GC)
形式oil
颜色 colorless to yellow
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品