TETi76 diethyl ester

产品名称：

1451750-73-4
TETi76 diethyl ester
AD145
Diethyl 2-hydroxy-4-methylenepentanedioate
TETi76 ester
2-Hydroxy-4-methylene-pentanedioic acid, 1,5-diethyl ester

产品介绍：

产品说明

生化/生理作用

TETi76 diethyl ester is a cell-permeant diester form of the α-KG-competitive and hightly selective TET1/2/3 dioxygenase inhibitor TETi76 acid (TET2 cat. domain Kd = 0.3 μM; no potency against 16 other αKG/Fe2+-dependent enzymes, including closely related RNA dioxygenase FTO). TETi76 ester downregulates cellular 5-hydroxymethylcytosine (5hmC) levels (IC50 = 20-37 μM; K562, MEG01, SIGM5, OCI-AML5, MOLM13), exerts preferential cytotoxicity in TET-deficient cultures (TET2/3-knockout K562 LD50 ~10 μM vs wt K562 LD50 ~40 μM) and significantly reduces TET2-deficient SIGM5 tumor burden in mice in vivo (50 mg/kg p.o.).

基本信息

经验(实验)分子式	C₁₀H₁₆O₅
分子量	216.23

产品性质

质量水平	100
测定	≥95% (GC)
形式	oil
颜色	colorless to yellow
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable