Tizoxanide

产品名称：

173903-47-4
Tizoxanide
2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide
Nitazoxanide metabolite
Desacetyl-NTZ
NTZ metabolite
Desacetyl-nitazoxanide
TIZ
2-Hydroxy-N-(5-nitrothiazol-2-yl)benzamide
NSC 697856

产品介绍：

产品说明

生化/生理作用

Tizoxanide (TIZ) is the active metabolite of the broad-spectrum parasiticidal drug nitazoxanide (NTZ), a noncompetitive inhibitor against bacterial pyruvate-ferredoxin oxidoreductase (PFOR K_i 2 to 10 μM). NTZ deacetylates rapidly to TIZ in plasma (t_1/2 ~6 min at 37℃ in human plasma) and in the presence of liver microsomes. NTZ is also reported to exhibit antiviral activity against Hepatitis C, Norovirus, Paramyxovirus, Influenza, Vaccinia, and Zika.

基本信息

经验(实验)分子式	C₁₀H₇N₃O₄S
分子量	265.25
MDL编号	MFCD07484970

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	OC1=C(C(NC2=NC=C([N+]([O-])=O)S2)=O)C=CC=C1

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable