产品说明
应用
TN-16 has been used as a microtubule disrupting agent to study its effect on autophagic process in human and mouse mammary carcinoma cell lines .
包装
5, 25 mg in glass bottle
生化/生理作用
3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16), a tenuazonic acid derivative, is a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase. It is a colchicine site binding agent and a powerful autophagy flux inhibitor that could be used as a conventional autophagy inhibitor with anti-cancer potential in pre-clinical trials.
TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. It can prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.
Inhibitor of microtubule assembly
基本信息
| 经验(实验)分子式 | C19H18N2O2 |
| 分子量 | 306.36 |
| PubChem化学物质编号 | 329826871 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to tan |
| 溶解性 | DMSO: ≥17 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | C\C(Nc1ccccc1)=C2\C(=O)NC(Cc3ccccc3)C2=O |
| InChI | 1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13- |
| InChI key | KWSXUGYAGMSUTN-LGMDPLHJSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H317 - H400 |
| 预防措施声明 | P273 - P280 - P302 + P352 |
| 危险分类 | Aquatic Acute 1 - Skin Sens. 1 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
