AA74-1

产品名称：

1361532-00-4
AA74-1
[4-[1-Hydroxy-3-methyl-1-(2-methylpropyl)butyl]-2H-1,2,3-triazol-2-yl]-1-pyrrolidinylmethanone
[4-(4-Hydroxy-2,6-dimethylheptan-4-yl)-2H-1,2,3-triazol-2-yl](pyrrolidin-1-yl)methanone

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

AA74-1 is an extremely potent and selective inhibitor of the serine hydrolase acyl-peptide hydrolase (APEH) with an IC₅₀ of 5 nM in mouse T-cell proteomes. AA74-1 potently blocked the activity of its target serine hydrolase, APEH, in mice in vivo without significantly affecting other enzymes. The APEH inhibition caused accumulation of N-acetylated proteins and stimulated cellular proliferation in T cells.

The APEH gene is deleted in some cancers, in which it has been proposed to serve as a potential tumor suppressor, and is involved in the degradation of oligomeric amyloid-beta which could make it a new target for therapy aimed at reducing neurodegeneration in Alzheimer′s disease. AA74-1 is the first selective tool for studying APEH activity.

基本信息

经验(实验)分子式	C₁₆H₂₈N₄O₂
分子量	308.42
MDL编号	MFCD23704789
PubChem化学物质编号	329825360
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	film
颜色	colorless
溶解性	DMSO: >15 mg/mL
储存温度	2-8℃
SMILES string	CC(C)CC(O)(CC(C)C)c1cnn(n1)C(=O)N2CCCC2
InChI	1S/C16H28N4O2/c1-12(2)9-16(22,10-13(3)4)14-11-17-20(18-14)15(21)19-7-5-6-8-19/h11-13,22H,5-10H2,1-4H3
InChI key	GXBVPGCIMCIASQ-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable