Bis-Imidazole phenol IDH1 inhibitor

产品名称：

1648909-73-2
Bis-Imidazole phenol IDH1 inhibitor
2,6-Bis((1H-Imidazol-1-yl)methyl)-4-(2,4,4-trimethylpentan-2-yl)phenol

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

bis-Imidazole phenol is a potent and cell permeable inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant R132H that inhibits D-2-hydroxyglutaric acid (2HG) production in cells. bis-Imidazole phenol binds to an IDH1 R132H allosteric site at the dimer interface containing residue involved in binding of the catalytically essential divalent cation.
Bis-imidazole phenol blocks D-2-hydroxyglutaric acid synthesis in cells.

基本信息

经验(实验)分子式	C₂₂H₃₀N₄O
分子量	366.50
PubChem化学物质编号	329825871
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 30 mg/mL, clear
储存温度	2-8℃
SMILES string	OC1=C(CN2C=CN=C2)C=C(C(C)(CC(C)(C)C)C)C=C1CN3C=NC=C3
InChI	1S/C22H30N4O/c1-21(2,3)14-22(4,5)19-10-17(12-25-8-6-23-15-25)20(27)18(11-19)13-26-9-7-24-16-26/h6-11,15-16,27H,12-14H2,1-5H3
InChI key	PCIJWPBOCDNTJF-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable