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AF-DX 116

品牌
Sigma-Aldrich
CAS
102394-31-0
货号
SML0435
规格纯度
≥98% (HPLC)
参考价格
1290.53 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
102394-31-0
AF-DX 116
Otenzepad
11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,1 1-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
产品介绍:

产品说明

应用

AF-DX 116 has been used as an M2 muscarinic acetylcholine receptor (M2AChR) selective antagonist to study the influence of M2AChR in the regulation of both basal and carbachol-stimulated long-term potentiation at the dentate gyrus (DG-LTP) and pro-nerve growth factor (proNGF) secretion in hippocampal cells of young diabetic rats.

包装

5, 25 mg in glass bottle

生化/生理作用

AF-DX 116 raises blood pressure and heart rate in a rat model of hypotension induced by repeated cold stress. Thus, it may be used as a therapeutic for hypotension related to vagotonia type autonomic dysfunction.
AF-DX 116 is a selective M2 muscarinic acetylcholine receptor antagonist.

特点和优势

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C24H31N5O2
分子量421.54
MDL编号MFCD00864743
PubChem化学物质编号329824718
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
drug controlregulated under CDSA - not available from sigma-aldrich Canada
颜色 white to beige
溶解性DMSO: 5 mg/mL (clear solution; warmed)
储存温度room temp
SMILES stringCCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
InChI1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
InChI keyUBRKDAVQCKZSPO-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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