AZ32

产品名称：

2288709-96-4
AZ32
N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide

产品介绍：

产品说明

生化/生理作用

AZ32 is an orally active, potent and selective ataxia telangiectasia mutated (ATM) kinase inhibitor (IC₅₀ <6.2 nM; DNA-PK & PI3Ka IC₅₀ =4.6 μM, hERG IC₅₀ = 17.6 μM) with good aqueous solubility (24 μM) and blood-brain barrier (BBB) permeability in mice (free brain/plasma ratio = 0.26; 200 mg/kg p.o.). AZ32 exhibits radiosensitizing efficacy in human & murine glioma cultures by blocking radiation-induced DNA damage response (ATM pS1981 IC₅₀ = 310 nM; 100% blockage of KAP1 pS824 & p53 pS15 at 300 nM; T98G cells). AZ32 (200 mg/kg/day p.o.) improves whole-head irradiation treatment survival rate among mice with brain GL261 tumors or NCI-H2228 NSCLC metastases in vivo.

基本信息

经验(实验)分子式	C₂₀H₁₆N₄O
分子量	328.37
MDL编号	MFCD31715431

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable