Betrixaban

产品名称：

330942-05-7
Betrixaban
N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide
MK-4448
PRT-054021
PRT054021
MLN1021
N-(5-Chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide

产品介绍：

产品说明

生化/生理作用

Betrixaban is an orally active, active site-targeting, highly potent and selective factor Xa (fXa) inhibitor (IC₅₀ = 1.5 nM; K_i = 117 pM) with much reduced plasma kallikrein inhibitory activity (IC₅₀ = 6.3 μM) and little potency against thrombin, trypsin, t-PA, aPC or plasmin inhibition (IC₅₀ >10 μM). Betrixaban exhibits good pharmacokinetic properties and anticoagulant efficacy against various thromboembolism (VTE) events in vivo.

基本信息

经验(实验)分子式	C₂₃H₂₂ClN₅O₃
分子量	451.91
MDL编号	MFCD16038040

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	ClC1=CN=C(C=C1)NC(C2=C(NC(C3=CC=C(C(N(C)C)=N)C=C3)=O)C=CC(OC)=C2)=O

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H373
预防措施声明	P301 + P312 + P330 - P314
危险分类	Acute Tox. 4 Oral - STOT RE 2
靶器官	Blood
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable