cRIPGBM

产品名称：

2361988-77-2
cRIPGBM
RIPGBM proapoptic metabolite
1-Benzyl-3-(4-fluorobenzyl)-2-methyl-4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium chloride

产品介绍：

产品说明

生化/生理作用

cRIPGBM is an apoptosis inducer (GBM-1/-5/-39 EC₅₀ = 63/95/290 nM; human neural progenitor cells (NPCs)/astrocytes/lung fibroblasts EC₅₀ = 190/710/960 nM) that binds receptor-interacting protein kinase 2 (RIPK2, RIP2) and promotes the formation of a proapoptotic RIPK2/caspase-1 complex. Cell type-selective metabolic redox conversion of RIPGBM to cRIPGBM in glioblastoma multiforme (GBM) cancer stem cells (CSCs) form the basis of selective GBM CSCs apoptosis induction by RIPGBM over non-GBM cultures.

基本信息

经验(实验)分子式	C₂₆H₂₀ClFN₂O₂
分子量	446.90

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C1C2=C([N+](CC3=CC=C(F)C=C3)=C(C)N2CC4=CC=CC=C4)C(C5=C1C=CC=C5)=O.[Cl-]

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable