CLP257

产品名称：

1181081-71-9
CLP257
(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone

产品介绍：

产品说明

应用

CLP257 has been used as a K⁺- Cl^-cotransporter 2 (KCC2) enhancer in human neuron culture.

包装

5, 25 mg in glass bottle

生化/生理作用

CLP257 is a selective K⁺-Cl⁻ cotransporter KCC2 activator that restored impaired Cl⁻ transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.
In streptozotocin treated rats, by activating a K⁺- Cl^-cotransporter 2 (KCC2) in the arginine-vasopressin neuron, CLP257 mediates γ-aminobutyric acid (GABA)ergic excitation. It is however inactive with KCC1, KCC3 and KCC4.

基本信息

经验(实验)分子式	C₁₄H₁₄FN₃O₂S
分子量	307.34
MDL编号	MFCD28166488
PubChem化学物质编号	329825822
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	, white to yellow to light brown
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O
InChI	1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-
InChI key	SKCADXVKQRCWTR-GHXNOFRVSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable