BMS-299897

产品名称：

290315-45-6
BMS-299897
2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid

产品介绍：

产品说明

应用

BMS-299897 has been used as an γ-secretase inhibitor to stop high glucose (HG) mediated amyloid β-peptide (Aβ) secretion.

包装

5, 25 mg in glass bottle

生化/生理作用

BMS-299897 may be used as a therapeutic for Alzheimer′s disease.
BMS-299897 is a potent inhibitor of γ-secretase. The comound is 15-fold more selective for inhibiting the cleavage of β-amyloid precursor protein over Notch cleavage (IC₅₀s 7.1 and 105.9, respectively). In vivo, BMS-299897 blocks the formation of Aβ40 and Aβ42 in the brain and CSF without affecting maturation of CD8⁺T cells or intestinal goblet cells, suggesting Notch signalling was not significantly inhibited.

基本信息

经验(实验)分子式	C₂₄H₂₁ClF₃NO₄S
分子量	511.94
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: ≥20 mg/mL
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable