CAY10566

产品名称：

944808-88-2
CAY10566
SCD1 inhibitor 28c
2-(6-(4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole
Abbott-28c
CAY-10566
CAY 10566
Abbott compound 74

产品介绍：

产品说明

生化/生理作用

CAY10566 is a potent and selective stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 26 nM/hSCD1 and 4.5 nM/mSCD1; IC50 >10 μM/75 receptors, transporters, ion channels). CAY10566 effectively blocks the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50 = 7.9 nM by C17:1/C17:0 ratio; IC50 = 6.8 nM by C16:1/C16:0 ratio) and exhibits good metabolic stability (by rat & mouse liver microsome assays) and oral availability (rat F = 59.2%; 5 mg/kg p.o.). CAY10566 is typically used in the range from 0.1-10 μM for cell treatment.

基本信息

经验(实验)分子式	C₁₈H₁₇ClFN₅O₂
分子量	389.81
MDL编号	MFCD11976899

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	off-white to orange
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable