4-Amidino-1-indanone-2′-amidinohydrazone dihydrochloride

产品名称：

138794-73-7
CGP 48664 dihydrochloride
4-Amidino-1-indanone-2′-amidinohydrazone dihydrochloride
4-Amidinoindan-1-one-2?-amidinohydrazone dihydrochloride
CGP48664 dihydrochloride
(E)-2-[4-(Aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide dihydrochloride
SAM486A dihydrochloride
Sardomozide dihydrochlorid
CGP 48664A dihydrochloride
CMA 48664 dihydrochloride
Sardomozide dihydrochloride
(E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide dihydrochloride

产品介绍：

产品说明

生化/生理作用

CGP 48664 (SAM486A; Sardomozide) is a polyamine (PA) biosynthesis inhibitor (73% and 97% downregulation of murine leukemia L1210 cellular spermidine and spermine, respectively, by 0.5 μM Sardomozide in 4 days) that targets the rate-limiting enzyme S-adenosylmethionine decarboxylase (AdoMetDC, SAMDC, AMD1) in a potent (IC50 = 5 nM against rat AMD1) and selective manner with little or no inhibitory efficacy toward diamine oxidase or ornithine decarboxylase (IC50 = 18 μM and >50 μM against rat DAO and ODC, respectively). CGP 48664 effectively inhibits the proliferation of murine (GI50 = 0.5 μM against L1210 in 4 days) and human cancer cell lines in cultures (GI50 from 0.26 to 0.6 μM in 5 days; GI50 = 0.8 μM against human melanoma SK MEL-24 in 10 days) and suppresses the growth of murine and human tumor xenografts in mice in vivo (ED50 ≤0.5 mg/kg i.p.). CGP 48664 (Sardomozide) potently inhibits growth of PFA ependymoma cells.

基本信息

经验(实验)分子式	C₁₁H₁₄N₆· 2HCl
分子量	303.19
MDL编号	MFCD00910325

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	−20℃
SMILES string	NC(C1=CC=CC2=C1CC/C2=N\NC(N)=N)=N.Cl.Cl

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable