Fluorizoline

产品名称：

1362243-70-6
Fluorizoline
2,5-bis(4-Chlorophenyl)-4,4,5-trifluoro-4,5-dihydrothiazole
4,4,5-Trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole

产品介绍：

产品说明

生化/生理作用

Fluorizoline is a prohibitin (PHB) 1/2-binding diaryl trifluorothiazoline compound that induces p53-independent apoptosis in various cancer cultures (IC50 from 1.6 μM/Bx-PC3 to 9.4 μM/JeKo 1; 24 h) and upregulates proapoptotic Noxa and Bim mRNAs in wild-type, but not PHBs-depleted MEFs. Box(-/-)/Bak(-/-) or Noxa(-/-)/Bim(-/-) MEFs as well as BAX/BAK- or NOXA-downregulated HeLa cells are resistant to fluorizoline-induced apoptosis. Fluorizoline treatment is shown to prevent active RAS-CRAF interaction and downstream MEK1/2 activation following EGF stimulation in HeLa cells (10 μM).

基本信息

经验(实验)分子式	C₁₅H₈Cl₂F₃NS
分子量	362.20

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	ClC(C=C1)=CC=C1C2=NC(F)(F)C(C3=CC=C(Cl)C=C3)(F)S2

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable