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DREADD Agonist 21 dihydrochloride

品牌
Sigma-Aldrich
CAS
56296-18-5
货号
SML2392
规格纯度
≥98% (HPLC)
参考价格
1055.93 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
56296-18-5
DREADD Agonist 21 dihydrochloride
11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride
Compound 21 dihydrochloride
11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride
产品介绍:

产品说明

生化/生理作用

Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).

基本信息

经验(实验)分子式C17H18N4 · 2HCl
分子量351.27
MDL编号MFCD25121806

产品性质

测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 yellow to brown
溶解性H2O: 2 mg/mL, clear
储存温度−20℃
SMILES stringC1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 + P330 - P501
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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