产品说明
生化/生理作用
Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).
基本信息
经验(实验)分子式 | C17H18N4 · 2HCl |
分子量 | 351.27 |
MDL编号 | MFCD25121806 |
产品性质
测定 | ≥98% (HPLC) |
形式 | powder |
储存条件 | desiccated |
颜色 | yellow to brown |
溶解性 | H2O: 2 mg/mL, clear |
储存温度 | −20℃ |
SMILES string | C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1 |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H302 |
预防措施声明 | P264 - P270 - P301 + P312 + P330 - P501 |
危险分类 | Acute Tox. 4 Oral |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |