产品说明
应用
GW833972A, a selective CB2 cannabinoid receptor agonist, may be used separately or in comparison to other cannabinoid receptor agonist and antagonists to differentiate and characterize the CB2 cannabinoid receptor. GW833972A may be used to help verify that an observed physiological response is cannabinoid receptor CB2-dependent.
包装
5, 25 mg in glass bottle
生化/生理作用
The compound was used to determine the role of CB2 in airway sensory nerve function.
GW833972A is a CB2 cannabinoid receptor agonist with 1000-fold selectivity relative to CB1. It is, however, 15-fold less potent than HU210 for CB2 (Ki 7.8 vs. 0.52 nM). The antitumor compound oxaliplatin induces marked hypersensitivity to cold, heat, and chemical pain stimuli (to the point where oxaliplatin therapy has to be discontinued). The hyperalgesia effect is almost completely blocked by pretreatment with GW833972A.
基本信息
| 经验(实验)分子式 | C18H13ClF3N5O · HCl |
| 分子量 | 444.24 |
| MDL编号 | MFCD18452844 |
| PubChem化学物质编号 | 329799976 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| drug control | regulated under CDSA - not available from sigma-aldrich Canada |
| 储存条件 | desiccated |
| 颜色 | off-white to light brown |
| 溶解性 | DMSO: ≥20 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | Cl.FC(F)(F)c1nc(Nc2cccc(Cl)c2)ncc1C(=O)NCc3ccncc3 |
| InChI | 1S/C18H13ClF3N5O.ClH/c19-12-2-1-3-13(8-12)26-17-25-10-14(15(27-17)18(20,21)22)16(28)24-9-11-4-6-23-7-5-11;/h1-8,10H,9H2,(H,24,28)(H,25,26,27);1H |
| InChI key | UBHSVFAUAKIVKL-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 - H315 - H319 - H335 - H413 |
| 预防措施声明 | P273 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 3 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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