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H-151

品牌
Sigma-Aldrich
CAS
941987-60-6
货号
SML2437
规格纯度
≥98% (HPLC)
参考价格
1172.42 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
941987-60-6
H-151
1-(4-Ethylphenyl)-3-(1H-indol-3-yl) urea
产品介绍:

产品说明

生化/生理作用

H-151 is an irreversible antagonist of the stimulator of interferon genes (STING) protein, a central signalling component of the cytosolic DNA sensing pathway. Although STING is a vital component of the innate immune pathways, it has also been shown to have a pathogenic role in some inflammatory diseases. H-151 is a potent and selective STING antagonist with inhibitory activity both in human cells and in vivo in mice. Given as a pretreatment, H-151 was shown to attenuate pathological features of autoinflammatory disease in mouse models, reducing systemic cytokine responses in mice treated with the STING agonist 10-carboxymethyl-9-acridanone (CMA)

基本信息

经验(实验)分子式C17H17N3O
分子量279.34
MDL编号MFCD08026581

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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