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KL-2

品牌
Sigma-Aldrich
CAS
900308-51-2
货号
SML2538
规格纯度
≥98% (HPLC)
参考价格
1021.62 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
900308-51-2
KL-2
N-(5-Chloro-2-methylphenyl)-4-(4-fluorophenyl)-2-hydroxy-4-oxo-2-butenamide
产品介绍:

产品说明

生化/生理作用

Disruptor of SEC (super elongation complex)
KL-2 is a disruptor of the super elongation complex (SEC). KL-1 blocks the interactions of positive transcription elongation factorb (P-TEFb) and the SEC-scaffolding protein AFF4 resulting in decreased Polymerase II (Pol II) activity and production of Pol II-transcribed genes. KL-2 was shown to cause downregulation of heat shock genes, and was non-toxic and active in an animal model of cancer.

基本信息

经验(实验)分子式C17H13ClFNO3
分子量333.74

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringCC1=CC=C(Cl)C=C1NC(/C(O)=C/C(C2=CC=C(F)C=C2)=O)=O

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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