ML375

产品名称：

1488362-55-5
ML375
ML 375
(S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one
VU0483253
(S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one

产品介绍：

产品说明

生化/生理作用

ML375 is an orally active, brain-penetrant, potent and M5 subtype-selective muscarinic acetylcholine receptor (mAChR) negative allosteric modulator (NAM) (IC₅₀ = 300/790 nM against 10 μM NMS-induced Ca²⁺ mobilization in h/r M5-transfected CHO cells; h/r M1-M4 IC₅₀ >30 μM) that reduces N-methylscopolamine (NMS) ML5 dissociation rate without competing against NMS for receptor binding. M375 shows in vivo efficacy in rat models of substances addiction (cocaine, ethanol, oxycodone) with excellent multispecies pharmacokinetic properties.

基本信息

经验(实验)分子式	C₂₃H₁₅ClF₂N₂O₂
分子量	424.83
MDL编号	MFCD28411378

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -150 to -175, c = 0.5 in chloroform-d
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable