LDN-27219

产品名称：

312946-37-5
LDN-27219
2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-acetic acid hydrazide

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

LDN-27219 is a thieno[2,3-d]pyrimidine-4-one-acylhydrazide derivative. Closed conformation of TG2 induced by LDN-27219 can be a potential therapeutic strategy for age-related vascular dysfunction and lowering blood pressure.
LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2) that binds to the GTP binidng site of the enzyme and inhbits activity with and IC₅₀ of 600 nM.

基本信息

经验(实验)分子式	C₂₀H₁₆N₄O₂S₂
分子量	408.50
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 15 mg/mL, clear
储存温度	−20℃

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable