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MDL-800

品牌
Sigma-Aldrich
CAS
2275619-53-7
货号
SML2529
规格纯度
≥98% (HPLC)
参考价格
1453.88 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
2275619-53-7
MDL-800
Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate
产品介绍:

产品说明

生化/生理作用

MDL-800 is a selective allosteric activator of SIRT6, a member of the SIRT deacetylase family that is responsible for deacetylation of histones H3K9Ac and H3K56ac and has tumor suppressor activity. MDL-800 increased the deacetylase activity of SIRT6 by up to 22-fold resulting in a decrease in H3K9Ac and H3K56Ac in hepatocellular carcinoma (HCC) cells, causing cell cycle arrest and inhibiting their proliferation. It also suppressed the growth of xenografts of the hepatocellular carcinoma cell line BEL7405.

基本信息

经验(实验)分子式C21H16BrCl2FN2O6S2
分子量626.30
MDL编号MFCD31813709

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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