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ML252

品牌
Sigma-Aldrich
CAS
1392494-64-2
货号
SML0723
规格纯度
≥98% (HPLC)
参考价格
1129.94 *本价格含增值税费
促销
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数量
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产品名称:
1392494-64-2
ML252
(S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

ML252 is a potent, brain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor with an IC50 of 69 nM. ML252 is only slightly selective over KCNQ3 and KCNQ4 but is over 40-fold selective for KCNQ2 vs KCNQ1, unlike other KCNQ inbhibitors currently used. ML252 was also selective vs. >68 tested GPCRs, ion channels, and transporters. Potassium channel Kv7.2 has become a new target for Alzheimer′s Disease drug research because inhibiting it enhances acetylcholine release. SAR studies showed a small structural change from ethyl group to hydrogen resulted in a functional shift from antagonist to agonist activity (37, EC50 of 170 nM), suggesting an interaction at a critical site for controlling KCNQ2 channel gating.

基本信息

经验(实验)分子式C20H24N2O
分子量308.42
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色, light to dark purple
溶解性DMSO: 25 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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