MG149

产品名称：

1243583-85-8
MG149
MG 149
2-(4-Heptylphenethyl)-6-hydroxybenzoic acid
2-[2-(4-Heptylphenyl)ethyl]-6-hydroxybenzoic acid

产品介绍：

产品说明

生化/生理作用

MG149 is cell-permeable anacardic acid analog that displays higher selectivity towards MYST type HATs (IC50 = 47 and 74 μM against MOF and Tip60; Ki for KAT8 = 39 μM) over p300 and PCAF (IC50 > 200 and >> 200 uM). Tip60 inhibition is shown to be Ac-CoA competitive and histone substrate non-competitive and KAT8 inhibition is Ac-CoA uncompetitive. MG149 treatment lowers histone acetylation levels and cellular proliferation rate, induces apoptosis and dose-dependently alters pro-inflammatory cytokines/chemokines expression. Enhances JQ1-induced HIV latency reversal, suppresses NOX transcription and ameliorates ROS levels.

基本信息

经验(实验)分子式	C₂₂H₂₈O₃
分子量	340.46
MDL编号	MFCD22123243

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	OC1=C(C(CCC2=CC=C(C=C2)CCCCCCC)=CC=C1)C(O)=O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable