ML365

产品名称：

947914-18-3
ML365
ML 365
2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide

产品介绍：

产品说明

生化/生理作用

Orignially characterized as an mGluR5 negative allosteric modulator (IC50 = 1.35 μM, E_max = 3.82% of Glu E_max; rat mGluR5 HEK293A cells), ML365 is now better known as selective two-pore potassium (K2P) channel TASK1 (K2P3.1; KCNK3) inhibitor with 100- and 62-fold selectivity over TASK3 (K2p9.1; KCNK9), respectively, by thellium flux (rat TASK1/TASK3 CHO cell IC50 = 4/390 nM) and QPatch assay (rat TASK1/TASK3 CHO cell IC50 = 16/990 nM). ML365 is employed in the range from 40 nM to 20 μM. Selective TASK1 blockage is achieved at the lower end of the concentration range, while TASK3 activity can also be inhibited at the high end of the range.

基本信息

经验(实验)分子式	C₂₂H₂₀N₂O₃
分子量	360.41
MDL编号	MFCD09204310

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable