Nexinhib20

产品名称：

331949-35-0
Nexinhib20
4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one
4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-one

产品介绍：

产品说明

生化/生理作用

Nexinhib20 (neutrophil exocytosis inhibitor 20) is a potent inhibitor of the interaction between the small GTPase Rab27a and its effector JFC1 (synaptotagmin-like protein1). Nexinhib20 inhibits exocytosis of azurophilic granules in human neutrophils without affecting other important innate immune responses including phagocytosis and neutrophil extracellular trap production.
Nexinhib20 prevents the expression of cytochrome b558 in the plasma membrane. It modulates vesicular trafficking and neutrophil activities. Nexinhib20 reduces the systemic inflammation, mediated by neutrophils.

基本信息

经验(实验)分子式	C₁₅H₁₆N₄O₃
分子量	300.31
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable