MSAB

产品名称：

173436-66-3
MSAB
Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate
3-[[(4-Methylphenyl)sulfonyl]amino]-benzoic acid methyl ester
WI-21

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.

基本信息

经验(实验)分子式	C₁₅H₁₅NO₄S
分子量	305.35
PubChem化学物质编号	329826041

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
颜色	off-white to purple
溶解性	DMSO: 25 mg/mL, clear
储存温度	2-8℃
SMILES string	CC1=CC=C(S(NC2=CC(C(OC)=O)=CC=C2)(=O)=O)C=C1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable