NGB 2904 hydrochloride

产品名称：

189061-11-8
NGB 2904 hydrochloride
N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride

产品介绍：

产品说明

应用

NGB 2904 hydrochloride may be used in cell signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

Inhibition of dopamine D₃ receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.
NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.

特点和优势

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₂₈H₂₉Cl₂N₃O·HCl
分子量	530.92
MDL编号	MFCD09971107
PubChem化学物质编号	329825130
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to tan
溶解性	DMSO: ≥25 mg/mL
储存温度	2-8℃
SMILES string	Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
InChI	1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H
InChI key	PFIWYJNBKGCVFM-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable