PAC-1

产品名称：

315183-21-2
PAC-1
1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide
(4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide

产品介绍：

产品说明

一般描述

Procaspase-activating compound 1 (PAC-1) is an ortho-hydroxy N-acyl hydrazine compound. It is cytotoxic to a variety of cancer cells, such as lymphoma, leukaemia, breast carcinoma and glioblastoma. High doses of PAC-1 can promote neuroexcitation. It helps in the in vitro autoactivation of the proenzyme protease, which acts as a prototype for other protease activating compounds. PAC-1 dependant activation of procaspase-3 is associated with the chelation of zinc.

包装

5, 25 mg in glass bottle

生化/生理作用

PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC₅₀ for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC₅₀ for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.

特点和优势

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₂₃H₂₈N₄O₂
分子量	392.49
MDL编号	MFCD03302441
PubChem化学物质编号	329820019
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	white
溶解性	DMSO: ≥10 mg/mL deionized water: ≤2 mg/mL
储存温度	room temp
SMILES string	Oc1c(CC=C)cccc1\C=N\NC(=O)CN2CCN(CC2)Cc3ccccc3
InChI	1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16+
InChI key	YQNRVGJCPCNMKT-LFVJCYFKSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves